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闻志强

作者: 时间:2021-11-23 点击数:


姓名: 闻志强        职称:讲师

联系方式:

电子邮箱:zqwen@njnu.edu.cn

通信地址:南京师范大学学林路2号食品与制药工程学院

教育背景:

20049月~20086月就读于郑州大学化学工程与工艺专业,获学士学位;

20089月~20149月就读于浙江大学化工学院生物化工专业,林建平/杨立荣课题组,获博士学位;

研究经历:

20149月~201611月于中科院上海生命科学研究院/中科院合成生物学重点实验室杨晟课题组受博士后训练;

20164月~20166月赴英国诺丁汉大学合成生物学研究中心Nigel Minton课题组访学;

201611月~20206月于南京理工大学环境与生物工程学院,任讲师;

20206月加入南京师范大学食品与制药工程学院黄和教授课题组

主要研究方向:

立足微生物合成生物学,面向医药工业需求,致力于药用化学品或生物制品开发,具体包括(1)益生菌基因编辑工具开发及菌群代谢工程调控;(2)基于纳米抗体/mRNA的靶向药物设计与递送

主要社会兼职:

兼任PLOS ONE期刊学术编辑,Frontiers in Bioengineering and Biotechnology期刊客座编辑,及十余种SCI期刊审稿人。

近期发表论文(*通讯作者)

1. Huazhen Lu, Qingzhuo Wang, Wenzheng Liu, Zhiqiang Wen* & Yanan Li*. Precision strategies for cancer treatment by modifying the tumor-related bacteria. Applied Microbiology and Biotechnology. 2021, accepted. Doi: 10.1007/s00253-021-11491-9 (*co-corresponding author, TOP期刊, IF 4.813)

2. Qingzhuo Wang, Naief H Al Makishah, Yanan Li, Wenzheng Liu, Xiaoman Sun*, Zhiqiang Wen*, Sheng Yang. Developing Clostridia as cell factories for short and medium chain esters production. Frontiers in Bioengineering and Biotechnology, 2021, accepted. DOI: 10.3389/fbioe.2021.661694 (*co-corresponding author, TOP期刊, IF 5.890).

3. Qingzhuo Wang, Jiao Zhang, Naief H Al Makishah, Xiaoman Sun*, Zhiqiang Wen*, Yu Jiang, Sheng Yang. Advances and perspectives for genome editing tools of Corynebacterium glutamicum. Frontiers in Microbiology, 2021, 12: 654058. (*co-corresponding author, TOP期刊, IF 5.640).

4. 闻志强, 孙小曼, 汪庆卓, 李亚楠, 刘文正, 蒋宇, 杨晟*. 梭菌正丁醇代谢工程研究进展. 合成生物学. 2021, 2(2): 194 -221.

5. Zedi Wang, Linlin Zhou, Minrui Lu, Yuwei Zhang, Samina Perveen, Huarong Zhou, Zhiqiang Wen*, Zhaoxian Xu*, Mingjie Jin*: Adaptive laboratory evolution of Yarrowia lipolytica improves ferulic acid tolerance. Applied Microbiology and Biotechnology, 2021, 105(4): 1745-1758. (*co-corresponding author, TOP期刊, IF 4.813).

6. Dahui Fang, Zhiqiang Wen*, Minrui Lu, Ang Li, Yuheng Ma, Ye Tao, Mingjie Jin*. Metabolic and process engineering of Clostridium beijerinckii for butyl acetate production in one step. Jan, 2020, Journal of Agricultural and Food Chemistry, 2020, 68(35): 9475–9487. (*co-corresponding author, TOP期刊, IF 5.279, 内封面).

7. Zhiqiang Wen, Sufang Zhang#, Chuks Kenneth Odoh, Mingjie Jin*, Zongbao K. Zhao*. Rhodosporidium toruloides - A potential red yeast chassis for lipids and beyond. FEMS Yeast Research, 2020, 20 (5): foaa038 (IF 2.796).

8. Lin Lin Zhou, Zhiqiang Wen*, Zedi Wang, Yuwei Zhang, Rodrigo Ledesma-Amaro, Mingjie Jin*. Evolutionary engineering improved D-glucose/xylose co- fermentation of Yarrowia lipolytica. Industrial & Engineering Chemistry Research, 2020, 59(39): 17113–17123. (*co-corresponding author, TOP期刊, IF 3.720).

9. Zhiqiang Wen, Rodrigo Ledesma-Amaro, Minrui Lu, Yu Jiang, Mingjie Jin*, Sheng Yang*. Combined evolutionary engineering and genetic manipulation improve low pH tolerance and butanol production in a synthetic microbial community of Clostridium. Biotechnology and Bioengineering, 2020, 117(7): 2008-2022. (TOP期刊, IF 4.530, 内封面).

10. Ang Li#, Zhiqiang Wen#, Dahui Fang, Minrui Lu, Yuheng Ma, Qian Xie, Mingjie Jin*. Developing Clostridium diolis as a biorefinery chassis by genetic manipulation. Bioresource Technology, 2020, 305, 123066, doi: 10.1016/j.biortech.2020.123066. (#co-author, TOP期刊, IF 9.642)

11. Zhiqiang Wen, Rodrigo Ledesma-Amaro, Minrui Lu, Mingjie Jin*, Sheng Yang*. Metabolic Engineering of Clostridium cellulovorans to Improve Butanol Production by Consolidated Bioprocessing. ACS Synthetic Biology, 2020, 9(2): 304-315. (TOP期刊, IF 5.110)

12. Zhiqiang Wen, Minrui Lu, Rodrigo Ledesma-Amaro, Qi Li, Mingjie Jin*, Sheng Yang*. TargeTron Technology Applicable in Solventogenic Clostridia: Revisiting 12 Years' Advances. Biotechnology Journal, 2020, 15(1):1900284. (IF 4.677)

13. Zhiqiang Wen, Qi Li, Jinle Liu, Mingjie Jin*, Sheng Yang*. Consolidated bioprocessing for butanol production of cellulolytic Clostridia: development and optimization. Microbial biotechnology, 2020, 13(2), 410-422. (IF 5.813)

14. 马冬石、陈震、彭毅雯、闻志强*、金明杰. 红冬孢酵母分子遗传操作技术研究进展. 生物加工过程, 2019, 17(5): 504-508.

15. Zhiqiang Wen, Rodrigo Ledesma-Amaro, Jianping Lin*, Yu Jiang, Sheng Yang*. Improved n-Butanol Production from Clostridium cellulovorans by Integrated Metabolic and Evolutionary Engineering. Applied and Environmental Microbiology, 2019, 85 (7): e02560-18 (TOP期刊, IF 4.077, 当期亮点论文).

16. Zhiqiang Wen, Nigel Minton, Yin Zhang, Qi Li, Jinle Liu, Yu Jiang, Sheng Yang*. Enhanced solvent production by metabolic engineering of a twin-clostridial consortium. Metabolic engineering, 2017, 39:38-48. (TOP期刊, IF 7.674).

代表著作:

1. 闻志强, 林建平. 联合生物加工工艺法生产木质纤维素丁醇的研究进展. 2013工业生物技术发展报告 ( ISBN9787030390608). 马延和主编. 北京, 科学出版社.

2. Jin, Mingjie, Zhai Rui, Xu Zhaoxian, Wen Zhiqiang. Production of High-Value Polyunsaturated Fatty Acids Using Microbial Cultures. 2019, Methods in Molecular Biology: Microbial Lipid Production: Methods and Protocols (978-1-4939-9483-0, Editor: Venkatesh Balan. Humana, New York, NY.) 1995: 229-248.

3. 林建平, 闻志强, 林逸君, 朱力, 岑沛霖. 一种生产丁醇的方法. 专利号: CN 102643868 B, 授权日: 2013.11.20.

4. 林建平,闻志强,吴绵斌,岑沛霖,杨立荣. 一种利用木质纤维原料生产丙酮/丁醇的方法. 专利号:CN 104073526 B, 授权日: 2016.08.24.

5. 金明杰, 方大徽, 闻志强, 许召贤, 翟睿. 过表达 ATF 基因生产乙酸丁酯的拜氏梭菌, 中国发明专利, 2019, 申请号: 201910898097.5.

6. 金明杰, 李昂, 闻志强, 许召贤, 翟睿. 阻断甘油-葡萄糖代谢途径的 Diolis 梭菌碱基编辑突变株, 中国发明专利, 2019, 申请号:201910872091.0.

承担(参与)的主要科研项目:

1. 2021.7-2023.7,江苏省兽用生物制药高技术研究重点实验室开放课题,抗猪蓝耳病毒纳米抗体的筛选及工程益生菌递送研究,主持。

2. 2019.1-2020.12,浙江大学生物质化工教育部重点实验室开放课题,圆红冬孢酵母基因编辑工具开发及其在油脂分泌中的应用,2018BCE003,主持。

3. 2018.1-2020.12,国家自然科学基金青年基金,以氨基酸互养为约束条件的双梭菌菌群的设计与调控研究,21706133,主持。

4. 2018.1-2019.12,中央高校基本科研业务费,互营设计驱动仿生菌群高产燃料丁醇的研究,30918011310,主持。

5. 2015.11-2016.9,中国博士后科学基金面上项目,嗜纤维梭菌与拜氏梭菌统合生物加工菌群的建模与调控,2015M581675,主持。

6. 2014.1-2018.8973项目子课题:多细胞体系的设计及功能再造,2014CB745101973项目学术骨干。



南京师范大学食品与制药工程学院 ,南京市栖霞区学林路2号 TEL/FAX:86-25-85898183