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张幸

作者: 时间:2021-11-23 点击数:


姓名:张幸             职称:教授、博士生导师

联系方式:

电子邮箱:zhangxing@njnu.edu.cn

通信地址:南京师范大学学林路2号食品与制药工程学院

教育背景:

2005.07/2009.07 北京师范大学 学士学位

2009.09/2014.06 中国科学院大学 博士学位

工作经历:

2014.07/2015.04 中国科学院南海海洋研究所 助理研究员

2015.04/2018.06 伦斯勒理工学院  博士后

2018.06/2019.02 奥尔巴尼分子制药公司  研究科学家

2019.03/至今  南京师范大学 副教授、教授

主要研究方向:

生物催化与酶工程、糖生物医药工程、有机化学

主要社会兼职:

中国化工学会会员、中国生物工程学会会员、美国化学会会员;第八届江苏省青年科学家年会执行委员会委员;《Carbohydrate Polymers》、《Analytical Chemistry》等期刊审稿人

荣誉和获奖情况:

江苏特聘教授、江苏省双创博士;

南京师范大学中青年领军人才、鱼跃学者;

中国粮油学会科学技术奖二等奖,排第6

南京师范大学教学成果奖二等奖(高等教育类),排第1

南京师范大学本科生英才计划项目负责人;

国家级大学生创新创业训练计划项目,指导教师(20192020

近期发表论文(*通讯作者)

1. X. Zhang, X. Han, K. Xia, Y. Xu, Y. Yang, K. Oshima, S. M. Haeger, M. J. Perez, S. A. McMurtry, J. A. Hippensteel, J. A. Ford, P. S. Herson, J. Liu, E. P. Schmidt, R. J. Linhardt*, Proceedings of the National Academy of Sciences, USA. 2019, 116, 9208-9213. Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions.

2. X. Zhang, L. Lin, H. Huang*, R. J. Linhardt*, Accounts of Chemical Research 2020, 53, 335-346. Chemoenzymatic Synthesis of Glycosaminoglycans. 封面文章

3. X. Zhang, V. Pagadala, H. M. Jester, A. M. Lim, T. Q. Pham, A. M. P. Goulas, J. Liu*, R. J. Linhardt*. Chemical Science, 2017, 8, 7932-7940. Chemoenzymatic synthesis of heparan sulfate and heparin oligosaccharides and NMR analysis: Paving the way to a diverse library for glycobiologists.内封面文章

4. B. Z. Li*, A.Q. Xia, S. Y. Xie, L. Lin, Z. R. Ji, T. Y. Suo, X. Zhang*, H. Huang*. Analytical chemistry, 2021, 93, 3287-3294. Signal-amplified detection of the tumor biomarker FEN1 based on cleavage-induced ligation of a dumbbell DNA probe and rolling circle amplification.内封面文章

5. M. Qiao, B. Z. Li, Y. Ji, L. Lin, R. J. Linhardt*, X.Zhang*. Critical Reviews in Biotechnology, 2021, 41, 47-62. Synthesis of selected unnatural sugar nucleotides for biotechnological applications.

6. L. Liu, J. Dai, Y. Ji, B. Shen, X. Zhang*, R. J. Linhardt. Sensors and Actuators B: Chemical, 2021, 341, 130006. Detection of protamine and heparin using a promising metal organic frameworks based fluorescent molecular device BZA-BOD@ZIF-90.

7. L. Lin, M. Qiao, X. Zhang*, R. J. Linhardt*. Carbohydrate Polymers 2020, 230, 115643. Site-selective reactions for the synthesis of glycoconjugates in polysaccharide vaccine development.

8. B. X. Shen*, C. G. Ma, Y. Ji, J. N. Dai, B. Z. Li, X. Zhang*, H. Huang*. ACS Applied Materials & Interfaces, 2021, 13, 8718-8726. Detection of carboxylesterase 1 and chlorpyrifos with ZIF-8 metal-organic frameworks using a red emission BODIPY-based probe.

9. X. Zhang, D. E. Green, V. L. Schultz, L. Ling, X. R. Han, R. T. Wang, A. Yaksic, S. Y. Kim, P. L. DeAngelis*, R. J. Linhardt*. Journal of Organic Chemistry, 2017, 82, 9910-9915. Synthesis of 4-Azido-N-acetylhexosamine Uridine Diphosphate Donors: Clickable Glycosaminoglycans.

10. B. Z. Li*, P. Zhang, B. Zhou, S.Y. Xie, A. Q. Xia, T.Y. Suo, S. Feng*, X. Zhang*. Analytica Chimica Acta, 2021, 1148, 238194. Fluorometric detection of cancer marker FEN1 based on double-flapped dumbbell DNA nanoprobe functionalized with silver nanoclusters.

11. T. Y. Suo, M. Sohail, S. Y. Xie, B. Z. Li*, Y. Chen*, L.H. Zhang*, X. Zhang*. Journal of Hazardous Materials, 2021, 403, 123418. DNA nanotechnology: A recent advancement in the monitoring of microcystin-LR.

12. Y. Ji, Z. Z Wu, P. Zhang, M. Qiao, Y. Hu, B. X. Shen, B. Z. Li*, X. Zhang*. Biochemical Engineering Journal, 2021, 169, 107962. Enzyme-functionalized magnetic framework composite fabricated by one-pot encapsulation of lipase and Fe3O4 nanoparticle into metal-organic framework.

13. B. Z. Li, A.Q. Xia, S. L. Zhang, T. Y. Suo, Y. J. Ma, H. Huang*, X. Zhang*, Y. Chen*, X. M. Zhou*. Biosensors & Bioelectronics, 2021, 173, 112619. A CRISPR-derived biosensor for the sensitive detection of transcription factors based on the target-induced inhibition of Cas12a activation.

14. Z. R. Ji, Y. Ji, R. Ding, L. Lin, B. Z. Li*, X. Zhang*. Nanotechnology, 2021, 32, 195705. DNA-templated silver nanoclusters as an efficient catalyst for reduction of nitrobenzene derivatives: a systematic study.

15. L. Lin, B. Z. Li, X. R. Han, F. M. Zhang, X. Zhang*, R. J. Linhardt*. Analyst, 2021, 146, 714-720. A rolling circle amplification based platform for ultrasensitive detection of heparin.

16. H. Xu, B. X. Shen, M. Qiao, R. J. Linhardt*, X. Zhang*. Carbohydrate polymers, 2021, 258, 117672. Recent advances on the one-pot synthesis to assemble size-controlled glycans and glycoconjugates and polysaccharides.

17. J. Li, M. Qiao, Y. Ji, L. Lin, X. Zhang*, R. J. Linhardt*. International Journal of Biological Macromolecules 2020, 152, 199-206. Chemical, enzymatic and biological synthesis of hyaluronic acids.

18. M. Qiao, L. Lin, K. Xia, J. Li, X. Zhang*, R. J. Linhardt*. Talanta, 2020, 219,121270. Recent advances in biotechnology for heparin and heparan sulfate analysis.

19. T. Y. Suo, M. Sohail, Y. J. Ma, B. Z. Li*, Y. Chen*, X. Zhang*, X. M. Zhou*. Sensors and Actuators B-Chemical, 2020, 324, 128586. A versatile turn-on fluorometric biosensing profile based on split aptamers-involved assembly of nanocluster beacon sandwich.

20. B. Z. Li*, S. Y. Xie, A. Q. Xia, T. Y. Suo, H. Huang*, X. Zhang*, Y. Chen*, X. M. Zhou. TrAC-Trends in Analytical Chemistry, 2020, 132, 116039. Recent advance in the sensing of biomarker transcription factors.

21. Y. Ji, B. Z. Li, M. Qiao, J. M. Li, H. Xu, L. H. Zhang*, X. Zhang*. Applied Microbiology and Biotechnology, 2020, 104, 6587-6600. Advances on the in vivo and in vitro glycosylations of flavonoids.

22. B. X. Shen#, X. Zhang#, J. N. Dai, Y. Ji, H. Huang*. Journal of Hazardous Materials, 2020, 407, 124342. Lysosome targeting metal-organic framework probe LysFP@ZIF-8 for highly sensitive quantification of carboxylesterase 1 and organophosphates in living cells.

23. L.Lin, Y. Yu, F. Zhang, K. Xia, X. Zhang*, R. J. Linhardt*, Analyst 2019, 144, 4781-4786. Bottom-up and top-down profiling of pentosan polysulfate.

24. S. Cheng, P. L. Wantuch, M. E. Kizer, D. R. Middleton, R. Wang, M. DiBello, M. Li, X. Wang, X. Li, V. Ramachandiran, F.Y. Avci, F. Zhang, X. Zhang* , R. J. Linhardt*. Organic and Biomolecular Chemistry, 2019, 17, 2646–2650. Glycoconjugate synthesis using chemoselective ligation.

25. X. Zhang, D. M. Dickinson, L. Lin, M. Suflita, S. Baytas, R. J. Linhardt*, Tetrahedron Letters 2019, 60, 911-915. Chemoenzymatic synthesis of heparan sulfate tetrasaccharide from a N-acetyl-alpha-D-glucosamine-O-methylglycoside acceptor.

26. L.Lin, Y. Yu, F. Zhang, X. Zhang*, R. J. Linhardt*, Analytical Biochemistry, 2019, 586, 113419. High-throughput method for in process monitoring of 3-O-sulfotransferase catalyzed sulfonation in bioengineered heparin synthesis.

27. X. Zhang, K. Xia, L. Lin, F. Zhang, Y. Yu, K. St.Ange, X. Han, E. Edsinger, J. J. Sohn, R. J. Linhardt*. ACS Chemical Biology, 2018, 13, 1677-1685. Structural and functional components of the skate sensory organ ampullae of Lorenzini.

28. V. L. Schultz#, X. Zhang#, K. Linkens, J. Rimel, D. E. Green, P. DeAngelis, and R. J. Linhardt. Journal of Organic Chemistry, 2017, 82, 2243-2248. Chemoenzymatic Synthesis of 4-Fluoro-N-Acetylhexosamine Uridine Diphosphate Donors: Chain Terminators in Glycosaminoglycan Synthesis.

29. X. Zhang, Y. Xu, J. Liu, L. Lin, E. Schmidt, R.J. Linhardt*. Organic and Biomolecular Chemistry, 2017, 15, 1222-1227. Chemoenzymatic synthesis of unmodified heparin oligosaccharides: Cleavage of p-nitrophenyl glucuronide by alkaline and Smith degradation.

30. X. Zhang, O. Khalidi, S.-Y. Kim, R. Wang, V. Schultz, B. F. Cress, R. A. Gross, M. A.G. Koffas, R. J. Linhardt*. Bioorganic & Medicinal Chemistry Letters, 2016, 26, 3089-3092. Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents.

代表著作:

1. X. Zhang, R. J. Linhardt, Chapter 8 in Chemical Biology of Glycoproteins, Z. Tan and L.-X.Wang (Eds.), Royal Society of Chemistry, Cambridge, UK, 2017. Chemoenzymatic Synthesis of Low Molecular Weight Heparin and Heparan Sulfate.

2. 专利:一种吲哚-3-甲醛类化合物的制备方法和应用,ZL20141064108092017/01/12

3. 专利:一种海洋链霉菌及其应用,ZL20151007345082017/05/04

承担(参与)的主要科研项目:

1. 国家重点研发计划绿色生物制造重点专项,工业酶的智能设计与催化应用(2021YFC2100104),课题负责人, 2021-2024501万。

2. 国家自然科学基金青年项目,基于硫苷硫酸乙酰肝素的新型酶抑制剂的设计合成及抗肿瘤转移活性研究(22007049),主持人,2021-2023年,24万。

3. 江苏特聘教授,主持人,2020-2023年,100万。

4. 江苏省自然科学基金青年项目,新型乙酰肝素酶抑制剂的设计合成及抗肿瘤转移活性研究(BK20200728),主持人,2020-2022年,20万。

5. 横向:甾醇产品开发,主持人,2020-2022年,50万。


南京师范大学食品与制药工程学院 ,南京市栖霞区学林路2号 TEL/FAX:86-25-85898183