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2. He J, Wu L., Wei W., Meng S., Liu Z.T., Xu X., Pan H.X., Yang S., Liang Y.#, Zhou J.#, Tang G.L.#, (2023) Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis. Nature Catalysis, 6, 637–648.
3. Liu J., Lu J., Zhang C., Zhou Q., Jamieson C.S., Shang C., Houk K.N.#, Zhou J.#, Hu Y.# (2023). Tandem intermolecular [4 + 2] cycloadditions are catalysed by glycosylated enzymes for natural product biosynthesis. Naure Chemistry, 15, 1083–1090.
4. Ohashi M., Tan D., Lu J., Jamieson C.S., Kanayama D., Zhou J.#, Houk K.N.#, Tang Y.# (2023) Enzymatic cis-Decalin Formation in Natural Product Biosynthesis. J Am Chem Soc, 145(6): 3301-3305.
5. Zhang J., Hou X., Chen Z., Ko Y., Ruszczycky M.W., Chen Y., Zhou J.#, Liu H.W.# (2022) Dioxane bridge formation during the biosynthesis of spectinomycin involves a twitch radical SAM dehydrogenase that may have evolved from an epimerase. J Am Chem Soc, 144(22): 9910-9919.
6. Lee Y.H., Hou X., Chen R., Feng X., Liu X., Ruszczycky M.W., Gao J.M.#, Wang B.#, Zhou J.#, Liu H.W.# (2022) Radical S-Adenosyl methionine enzyme BlsE catalyzes a radical-mediated 1,2-diol dehydration during the biosynthesis of Blasticidin S. J Am Chem Soc, 144(10): 4478-4486.
7. Wu L., Wang Z., Cen Y.#, Wang B.#, Zhou J.# (2022) Structural insight into the catalytic mechanism of the endoperoxide synthase FtmOx1. Angew Chem Int Ed, 61(12): e202112063.
8. Wen W., Zhang Y., Zhang Y., Yu Q., Jiang C., Tang M., Pu J., Wu L., Zhao Y., Shi T., Zhou J.#, Tang G.L.# (2021) Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics. Nat Communications, 12(1): 7085.
9. Liu N., Wu L., Feng J., Sheng X.#, Li J., Chen X., Li J., Liu W., Zhou J.#, Wu Q.#, Zhu D.# (2021) Crystal structures and catalytic mechanism of L-erythro-3,5-diaminohexanoate dehydrogenase and rational engineering for asymmetric synthesis of β-amino acids, Angew Chem Int Ed, 60: 10203-10.
10. Gao D., Jamieson C.S., Wang G., Yan Y., Zhou J.#, Houk K.N.#, Tang Y.# (2021) A polyketide cyclase that forms medium-ring lactones. J Am Chem Soc, 143: 80-84.
11. Yan Y., Zang X., Jamieson C.S., Lin H., Houk K.N., Zhou J.#, Tang Y.# (2020). Biosynthesis of the fungal glyceraldehyde-3-phosphate dehydrogenase inhibitor heptelidic acid and mechanism of self-resistance. Chem Sci, 11(35): 9554-9562.
12. Ohashi M., Jamieson C.S., Cai Y., Tan D., Kanayama D., Tang M.C., Anthony S.M., Chari J.V., Barber J.S., Picazo E., Kakule T.B., Cao S., Garg N.K., Zhou J.#, Houk K.N.#, Tang Y.# (2020) An enzymatic Alder-ene reaction. Nature, 586(7827): 64-69.
13. Li A., Acevedo-Rocha C.G., D'Amore L., Chen J., Peng Y., Garcia-Borras M., Gao C., Zhu J., Rickerby H., Osuna S.#, Zhou J.#, Reetz M.T.# (2020) Regio- and stereoselective steroid hydroxylation at C7 by cytochrome P450 monooxygenase mutants. Angew Chem Int Ed, 59(30): 12499-12505.
14. Chen T., Chen J., Tang Y., Zhou J.#, Guo Y.#, Chang W.# (2020) Pathway from N-alkylglycine to alkylisonitrile catalyzed by Iron (II) and 2-oxoglutarate-dependent oxygenases. Angew Chem Int Ed, 59(19): 7367-7371.
15. Cai, Y., Hai Y., Ohashi M., Jamieson C.S., Garcia-Borras M., Houk K.N.#, Zhou J.#, Tang Y.# (2019) Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nature Chemistry, 11(9): 812-820.
16. Cen Y., Singh W., Arkin M., Moody T.S., Huang M., Zhou J.#, Wu Q.#, Reetz M.T.# (2019) Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution. Nature Communications, 10(1): 3198.
17. Xu J., Cen Y., Singh W., Fan J., Wu L., Lin X., Zhou J.#, Huang M.#, Reetz M.T.#, Wu Q.# (2019) Stereodivergent protein engineering of a lipase to access all possible stereoisomers of chiral esters with two stereocenters. J Am Chem Soc, 141(19): 7934-7945.
18. Zhou J., Wang Y., Xu G., Wu L., Han R., Schwaneberg U., Rao Y., Zhao Y.L., Zhou J.#, Ni Y.# (2018) Structural insight into enantioselective inversion of an alcohol dehydrogenase reveals a "polar gate" in stereorecognition of diaryl ketones. J Am Chem Soc, 140(39): 12645-12654.
19. Yan Y., Liu Q., Zang X., Yuan S., Bat-Erdene U., Nguyen C., Gan J., Zhou J.#, Jacobsen S.E.#, Tang Y.# (2018) Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action. Nature, 559(7714): 415-418.
20. Li Y., Zhang W., Zhang H., Tian W., Wu L., Wang S., Zheng M., Zhang J., Sun C., Deng Z., Sun Y., Qu X.#, Zhou J.# (2018) Structural basis of a broadly selective acyltransferase from the polyketide synthase of splenocin. Angew Chem Int Ed, 57(20): 5823-5827.
21. Sun Z., Wu L., Bocola M., Chan H.C.S., Lonsdale R., Kong X.D., Yuan S.#, Zhou J.#, Reetz M.T.# (2018) Structural and computational insight into the catalytic mechanism of limonene epoxide hydrolase mutants in stereoselective transformations. J Am Chem Soc, 140(1): 310-318.
22. Yuan H., Zhang J., Cai Y., Wu S., Yang K., Chan H.C.S., Huang W., Jin W.B., Li Y., Yin Y., Igarashi Y., Yuan S.#, Zhou J.#, Tang G.L.# (2017) GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. Nature Communications, 8(1): 1485.
23. Zhang J., Liu N., Cacho R.A., Gong Z., Liu Z., Qin W., Tang C., Tang Y.#, Zhou J.# (2016). Structural basis of nonribosomal peptide macrocyclization in fungi. Nature Chemical Biology, 12(12): 1001-1003.
24. Sun Z., Lonsdale R., Kong X., Xu J., Zhou J.#, Reetz M.R.# (2015). Reshaping an enzyme binding pocket for enhanced and inverted stereoselectivity: use of smallest amino acid alphabets in directed evolution. Angew Chem Int Ed, 54(42): 12410-12415.
25. Kong X., Yuan S., Li L., Chen S., Xu J.#, Zhou J.# (2014) Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. Proc Natl Acad Sci USA, 111(44): 15717-15722.
26. Kong X., Ma Q., Zhou J.#, Zeng B.#, Xu J.# (2014). A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-β-blocker precursors. Angew Chem Int Ed, 53(26): 6641-6644.
